Karl Fischer reagents are specifically designed to react quantitatively with water, enabling accurate measurement of moisture content in various samples. They typically consist of iodine, sulfur dioxide, a base (like imidazole or pyridine), and a suitable solvent (like alcohol). The reagents are used in both volumetric and coulometric Karl Fischer titrations. The general reaction is: H2O + I2 + SO2 + 3RN + ROH → (RNH)SO4R + 2(RNH)I.